Journal
CHEMICAL RECORD
Volume 16, Issue 4, Pages 1772-1786Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/tcr.201600005
Keywords
mirror-image phage display; molecular recognition; peptides; retro-inverso
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Funding
- National Science Foundation of China [81473148, 81473149]
- National Key Basic Research Program of China [2013CB932502]
- National Science and Technology Major Project [2012ZX09304004]
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Over recent years, D-peptides have attracted increasing attention. D-peptides increase enzymatic stability, prolong the plasma half-life, improve oral bioavailability, and enhance binding activity and specificity with receptor or target proteins, in comparison with the corresponding L-peptide. Therefore, D-peptides are considered to have potential as recognition molecules and therapeutic agents. This review focuses on the design and application of D-peptides with biological activity.
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