Journal
CHEMICAL RECORD
Volume 16, Issue 6, Pages 2659-2673Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/tcr.201600098
Keywords
asymmetric synthesis; enantioselectivity; hydrogenation; ligand design; rhodium
Categories
Funding
- Ministry of Education, Culture, Sports, Science and Technology of Japan
- Research for the Future Program of the Japan Society for the Promotion of Science
Ask authors/readers for more resources
In this account, the design, synthesis, and application of P-chirogenic phosphine ligands that have been mainly carried out in our laboratory over the last three decades are described. Various enantiopure P-chirogenic phosphine ligands have been efficiently prepared by using phosphine boranes as intermediates. Conformationally rigid and electron-rich P-chirogenic phosphine ligands possessing C-2 symmetry as well as a bulky alkyl group and a small group at the phosphorus atoms exhibit excellent enantioselectivities and catalytic efficiency in a variety of transition-metal-catalyzed asymmetric reactions. Enantiopure 2,3-bis(tert-butylmethylphosphino) quinoxaline (QuinoxP*) is an air-stable crystalline solid that shows superior enantioinduction ability in catalytic asymmetric syntheses. Mechanistic studies of Rh-catalyzed asymmetric hydrogenation using structurally simple P-chirogenic phosphine ligands, such as tBu-BisP*, are briefly described.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available