Journal
NEURON
Volume 106, Issue 5, Pages 778-+Publisher
CELL PRESS
DOI: 10.1016/j.neuron.2020.03.009
Keywords
-
Categories
Funding
- Fundacao para a Ciencia e Tecnologia (FCT) [SFRH/BPD/880972/2012, 030845]
- FEDER
- Gulbenkian Foundation
- Intramural Research Program of the NIMH [ZIA-MH002497-29]
- ERA-NET, ERC [COG 617142]
- HHMI [IEC 55007415]
- BIAL Foundation [176/10]
- AXA Research Fund
- Lisboa2020
- FCT [LISBOA-01-0145-FEDER-022170]
- research infrastructure Congento
- NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES [ZIAES103310] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF MENTAL HEALTH [ZIAMH002497] Funding Source: NIH RePORTER
Ask authors/readers for more resources
Postingestive nutrient sensing can induce food preferences. However, much less is known about the ability of postingestive signals to modulate food-seeking behaviors. Here we report a causal connection between postingestive sucrose sensing and vagus-mediated dopamine neuron activity in the ventral tegmental area (VTA), supporting food seeking. The activity of VTA dopamine neurons increases significantly after administration of intragastric sucrose, and deletion of the NMDA receptor in these neurons, which affects bursting and plasticity, abolishes lever pressing for postingestive sucrose delivery. Furthermore, lesions of the hepatic branch of the vagus nerve significantly impair postingestive-dependent VTA dopamine neuron activity and food seeking, whereas optogenetic stimulation of left vagus nerve neurons significantly increases VTA dopamine neuron activity. These data establish a necessary role of vagusmediated dopamine neuron activity in postingestive-dependent food seeking, which is independent of taste signaling.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available