Journal
NEUROIMAGE
Volume 212, Issue -, Pages -Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.neuroimage.2020.116637
Keywords
Gyrification; Aging; Cognition; Structural MRI
Funding
- European Research Council (ERC) under the European Union's Horizon 2020 research and innovation programme (project: ORACLE) [678543]
- European Research Council (ERC) under the European Union's Horizon 2020 research and innovation programme (project: EuroPOND) [666992]
- Sophia Foundation [S18-20]
- NWO Physical Sciences Division (Exacte Wetenschappen)
- SURFsara (Cartesius compute cluster)
- Erasmus Medical Center, Rotterdam
- Erasmus University, Rotterdam
- Netherlands Organization for the Health Research and Development (ZonMw)
- Research Institute for Diseases in the Elderly (RIDE)
- Ministry of Education, Culture and Science
- Ministry for Health, Welfare and Sports
- European Commission (DG XII)
- Municipality of Rotterdam
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Gyrification of the cerebral cortex changes with aging and relates to development of cognitive function during early life and midlife. Little is known about how gyrification relates to age and cognitive function later in life. We investigated this in 4397 individuals (mean age: 63.5 years, range: 45.7 to 97.9) from the Rotterdam Study, a population-based cohort. Global and local gyrification were assessed from T-1-weighted images. A measure for global cognition, the g-factor, was calculated from five cognitive tests. Older age was associated with lower gyrification (mean difference per year = -0.0021; 95% confidence interval = -0.0025; -0.0017). Non-linear terms did not improve the models. Age related to lower gyrification in the parietal, frontal, temporal and occipital regions, and higher gyrification in the medial prefrontal cortex. Higher levels of the g-factor were associated with higher global gyrification (mean difference per g-factor unit = 0.0044; 95% confidence interval = 0.0015; 0.0073). Age and the g-factor did not interact in relation to gyrification (p > 0.05). The g-factor bilaterally associated with gyrification in three distinct clusters. The first cluster encompassed the superior temporal gyrus, the insular cortex and the postcentral gyrus, the second cluster the lingual gyrus and the precuneus, and the third cluster the orbitofrontal cortex. These clusters largely remained statistically significant after correction for cortical surface area. Overall, the results support the notion that gyrification varies with aging and cognition during and after midlife, and suggest that gyrification is a potential marker for age-related brain and cognitive decline beyond midlife.
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