Journal
NEUROIMAGE
Volume 209, Issue -, Pages -Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.neuroimage.2019.116467
Keywords
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Funding
- Human Frontiers Science Program Cross-Disciplinary Postdoctoral Fellowship [LT000637/2016]
- National Institutes of Health [U01NS099724]
- Heritage Medical Research Institute
- Burroughs Wellcome Career Award at the Scientific Interface
- Pew Scholarship in the Biomedical Sciences
- Packard Fellowship for Science and Engineering
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Hemodynamic functional ultrasound imaging (fUS) of neural activity provides a unique combination of spatial coverage, spatiotemporal resolution and compatibility with freely moving animals. However, deep and transcranial monitoring of brain activity and the imaging of dynamics in slow-flowing blood vessels remains challenging. To enhance fUS capabilities, we introduce biomolecular hemodynamic enhancers based on gas vesicles (GVs), genetically encodable ultrasound contrast agents derived from buoyant photosynthetic microorganisms. We show that intravenously infused GVs enhance ultrafast Doppler ultrasound contrast and visually-evoked hemodynamic contrast in transcranial fUS of the mouse brain. This hemodynamic contrast enhancement is smoother than that provided by conventional microbubbles, allowing GVs to more reliably amplify neuroimaging signals.
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