Journal
NATURE MEDICINE
Volume 26, Issue 4, Pages 502-+Publisher
NATURE PORTFOLIO
DOI: 10.1038/s41591-020-0817-4
Keywords
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Funding
- National Key Research and Development Program of China [2019YFB1404803]
- Guangzhou Regenerative Medicine Guangdong Laboratory [2020GZR110306001]
- CDCs of Guangzhou City
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We report epidemiological and clinical investigations on ten pediatric SARS-CoV-2 infection cases confirmed by real-time reverse transcription PCR assay of SARS-CoV-2 RNA. Symptoms in these cases were nonspecific and no children required respiratory support or intensive care. Chest X-rays lacked definite signs of pneumonia, a defining feature of the infection in adult cases. Notably, eight children persistently tested positive on rectal swabs even after nasopharyngeal testing was negative, raising the possibility of fecal-oral transmission. Children infected with the COVID-19 outbreak coronavirus, SARS-CoV-2, show mild symptoms but prolonged shedding of viral RNA in feces, suggesting that the fecal-oral route might play a role in virus transmission.
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