Journal
NATURE MEDICINE
Volume 26, Issue 7, Pages 1037-+Publisher
NATURE PORTFOLIO
DOI: 10.1038/s41591-020-0916-2
Keywords
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Funding
- Zoe Global
- Wellcome Trust [212904/Z/18/Z]
- Medical Research Council/British Heart Foundation Ancestry and Biological Informative Markers for Stratification of Hypertension (AIMHY) [MR/M016560/1]
- European Union
- Chronic Disease Research Foundation
- NIHR Clinical Research Facility
- Biomedical Research Centre (based at Guy's and St Thomas' NHS Foundation Trust)
- King's College London
- Medical Research Council AIM HY project grant
- National Institute for Health Research Nottingham Biomedical Research Centre
- Alzheimer's Society Junior Fellowship [AS-JF-17-011]
- Wellcome/EPSRC Centre for Medical Engineering [WT203148/Z/16/Z]
- Wellcome Flagship Programme [WT213038/Z/18/Z]
- Evergrande COVID-19 Response Fund Award through the Massachusetts Consortium on Pathogen Readiness (MassCPR)
- UK Research and Innovation London Medical Imaging & Artificial Intelligence Centre for Value-Based Healthcare
- MRC [MR/M004422/1] Funding Source: UKRI
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A total of 2,618,862 participants reported their potential symptoms of COVID-19 on a smartphone-based app. Among the 18,401 who had undergone a SARS-CoV-2 test, the proportion of participants who reported loss of smell and taste was higher in those with a positive test result (4,668 of 7,178 individuals; 65.03%) than in those with a negative test result (2,436 of 11,223 participants; 21.71%) (odds ratio = 6.74; 95% confidence interval = 6.31-7.21). A model combining symptoms to predict probable infection was applied to the data from all app users who reported symptoms (805,753) and predicted that 140,312 (17.42%) participants are likely to have COVID-19. Analysis of data from a smartphone-based app designed for large-scale tracking of potential COVID-19 symptoms, used by over 2.5 million participants in the United Kingdom and United States, shows that loss of taste and smell sensations is predictive of potential SARS-CoV-2 infection.
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