Related references
Note: Only part of the references are listed.Biased Receptor Signaling in Drug Discovery
Terry Kenakin
PHARMACOLOGICAL REVIEWS (2019)
Illuminating G-Protein-Coupling Selectivity of GPCRs
Asuka Inoue et al.
CELL (2019)
Molecular pharmacology of metabotropic receptors targeted by neuropsychiatric drugs
Bryan L. Roth
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2019)
Mini G protein probes for active G protein-coupled receptors (GPCRs) in live cells
Qingwen Wan et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2018)
Glimmers in illuminating the druggable genome
Griffin Rodgers et al.
NATURE REVIEWS DRUG DISCOVERY (2018)
A FRET-based biosensor for measuring Gα13 activation in single cells
Marieke Mastop et al.
PLOS ONE (2018)
Lack of beta-arrestin signaling in the absence of active G proteins
Manuel Grundmann et al.
NATURE COMMUNICATIONS (2018)
Development of novel biosensors to study receptor-mediated activation of the G-protein subunits Gs and Golf
Hideaki Yano et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2017)
Discovery of new GPCR ligands to illuminate new biology
Bryan L. Roth et al.
NATURE CHEMICAL BIOLOGY (2017)
How Ligands Illuminate GPCR Molecular Pharmacology
Daniel Wacker et al.
CELL (2017)
Crystal Structure of an LSD-Bound Human Serotonin Receptor
Daniel Wacker et al.
CELL (2017)
Structure-based discovery of opioid analgesics with reduced side effects
Aashish Manglik et al.
NATURE (2016)
A randomized, phase 2 study investigating TRV130, a biased ligand of the mu-opioid receptor, for the intravenous treatment of acute pain
Eugene R. Viscusi et al.
PAIN (2016)
A New Generation of FRET Sensors for Robust Measurement of Gαi1, Gαi2 and Gαi3 Activation Kinetics in Single Cells
Jakobus van Unen et al.
PLOS ONE (2016)
Gaddum Memorial Lecture 2014: receptors as an evolving concept: from switches to biased microprocessors
Terry Kenakin
BRITISH JOURNAL OF PHARMACOLOGY (2015)
PRESTO-Tango as an open-source resource for interrogation of the druggable human GPCRome
Wesley K. Kroeze et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2015)
The experimental power of FR900359 to study Gq-regulated biological processes
Ramona Schrage et al.
NATURE COMMUNICATIONS (2015)
PRESTO-Tango as an open-source resource for interrogation of the druggable human GPCRome
Wesley K. Kroeze et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2015)
The G Protein-Biased kappa-Opioid Receptor Agonist RB-64 Is Analgesic with a Unique Spectrum of Activities In Vivo
Kate L. White et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2015)
Identification of Novel Functionally Selective κ-Opioid Receptor Scaffolds
Kate L. White et al.
MOLECULAR PHARMACOLOGY (2014)
A Simple Method for Quantifying Functional Selectivity and Agonist Bias
Terry Kenakin et al.
ACS CHEMICAL NEUROSCIENCE (2012)
Functional Selective Oxytocin-derived Agonists Discriminate between Individual G Protein Family Subtypes
Marta Busnelli et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2012)
Activation of ras-dependent signaling pathways by G14-coupled receptors requires the adaptor protein TPR1
Dawna H. T. Kwan et al.
JOURNAL OF CELLULAR BIOCHEMISTRY (2012)
Deciphering biased-agonism complexity reveals a new active AT1 receptor entity
Aude Sauliere et al.
NATURE CHEMICAL BIOLOGY (2012)
Real-time visualization of heterotrimeric G protein Gq activation in living cells
Merel J. W. Adjobo-Hermans et al.
BMC BIOLOGY (2011)
Functional Selectivity and Biased Receptor Signaling
Terry Kenakin
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2011)
Identification of a specific assembly of the G protein Golf as a critical and regulated module of dopamine and adenosine-activated cAMP pathways in the striatum
Denis Herve
FRONTIERS IN NEUROANATOMY (2011)
NMR analysis of G-protein βγ subunit complexes reveals a dynamic Gα-Gβγ subunit interface and multiple protein recognition modes
Alan V. Smrcka et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Structural basis for the specific inhibition of heterotrimeric Gq protein by a small molecule
Akiyuki Nishimura et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Heterotrimeric G proteins demonstrate differential sensitivity to β-arrestin dependent desensitization
Giulio Innamorati et al.
CELLULAR SIGNALLING (2009)
A unique mechanism of β-blocker action:: Carvedilol stimulates β-arrestin signaling
James W. Wisler et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Functional selectivity and classical concepts of quantitative pharmacology
Jonathan D. Urban et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2007)
Giα and Gβ subunits both define selectivity of G protein activation by α2-adrenergic receptors
SK Gibson et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
The receptors and coding logic for bitter taste
KL Mueller et al.
NATURE (2005)
Receptor-mediated activation of heterotrimeric G-proteins in living cells
C Janetopoulos et al.
SCIENCE (2001)
Visualization of a functional Gαq-green fluorescent protein fusion in living cells -: Association with the plasma membrane is disrupted by mutational activation and by elimination of palmitoylation sites, but not by activation mediated by receptors or Alf4-*S
TE Hughes et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Share Paper
