Journal
NATURE
Volume 581, Issue 7806, Pages 31-32Publisher
NATURE RESEARCH
DOI: 10.1038/d41586-020-01152-8
Keywords
Neurodegeneration; Alzheimer's disease
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Funding
- NINDS NIH HHS [R01 NS100447, R01 NS037853] Funding Source: Medline
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People who carry the gene variant APOE4 are at higher-than-average risk of developing Alzheimer's disease. It emerges that this variant is linked to defects in the blood-brain barrier and subsequent cognitive decline. A link between APOE4 and breakdown of the blood-brain barrier.
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