A new secoiridoid glycoside and other constituents from the roots and flowers of Fagraea fragrans Roxb. (Gentianaceae)

A new secoiridoid glycoside, 3'-O-p-trans-coumaroylsweroside (1), together with twenty-nine compounds (2-30), were isolated from the roots and flowers of Fagraea fragrans Roxb. (Gentianaceae). Their structures were identified by analysis of mass spectrometric and NMR spectroscopic data. Compounds 2, 4, 6, 11 and 13-15 showed weak to moderate cytotoxicity against cholangiocarcinoma cancer cells lines (KKU-213, KKU-055 and KKU-214). We report the first phytochemical investigation of the roots and flowers of F. fragrans, as only the essential oil of the latter has been investigated.

Automated summary

This study is the first phytochemical investigation of the roots and flowers of F. fragrans, leading to the isolation of a new secoiridoid glycoside and twenty-nine other compounds. Some of these compounds showed weak to moderate cytotoxicity against cholangiocarcinoma cancer cells lines, suggesting their potential for further study as anti-cancer agents.