New compounds from Japanese oak wilt disease-associated fungusRaffaelea quercivora

Two new compounds, a new lactone, quercilactone A (1), and (17R)-hydroxynafuredin (5), as well as five known compounds, scytalone (2), 3S,4R-hydoxy-scytalone (3), nafuredin (4), (+)-(3R,5R)-3-hydroxy-5-decanolide (6) and 3-ethyl-4-hydroxy-6-methyl-2H-pyran-2-one (7), were isolated fromRaffaelea quercivora, a fungus that causes Japanese oak wilt disease. The structures of these compounds were determined by 1D and 2D NMR spectroscopic analyses. The absolute configuration at C-17 of5was determined to beRby the modified Mosher's method. Compounds1,2, and7exhibited weak phytotoxic activity in lettuce seedlings at a concentration of 100 mu g mL(-1).

Automated summary

This study isolated seven compounds from a fungus causing Japanese oak wilt disease, including two new compounds. Compounds 1, 2, and 7 showed weak phytotoxic activity in lettuce seedlings.