Journal
NANOTECHNOLOGY
Volume 31, Issue 33, Pages -Publisher
IOP PUBLISHING LTD
DOI: 10.1088/1361-6528/ab8f4d
Keywords
nanopore; controlled dielectric breakdown; sodium hypochlorite; human serum transferrin; maltodextrin; nucleic acid
Funding
- National Science Foundation [1707818, 1712069, 1808344, 1150085]
- National Institutes of Health [R03EB022759]
- National Research Foundation of Korea [NRF-2015K1A4A3047100, NRF-2015M3A7B6027973, NRF-2015M3A6B3068660]
- URI Council for Research proposal development grant
- Direct For Mathematical & Physical Scien
- Division Of Chemistry [1808344] Funding Source: National Science Foundation
- Directorate For Engineering
- Div Of Civil, Mechanical, & Manufact Inn [1712069] Funding Source: National Science Foundation
- Div Of Civil, Mechanical, & Manufact Inn
- Directorate For Engineering [1707818] Funding Source: National Science Foundation
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Solid-state nanopores (SSNs) are single-molecule resolution sensors with a growing footprint in real-time bio-polymer profiling-most prominently, but far from exclusively, DNA sequencing. SSNs accessibility has increased with the advent of controlled dielectric breakdown (CDB), but severe fundamental challenges remain: drifts in open-pore current and (irreversible) analyte sticking. These behaviors impede basic research and device development for commercial applications and can be dramatically exacerbated by the chemical complexity and physical property diversity of different analytes. We demonstrate a SSN fabrication approach attentive to nanopore surface chemistry during pore formation, and thus create nanopores in silicon nitride (SiNx) capable of sensing a wide analyte scope-nucleic acid (double-stranded DNA), protein (holo-human serum transferrin) and glycan (maltodextrin). In contrast to SiNx pores fabricated without this comprehensive approach, the pores are Ohmic in electrolyte, have extremely stable open-pore current during analyte translocation (>1 h) over a broad range of pore diameters (less than or similar to
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