Journal
NANO RESEARCH
Volume 13, Issue 8, Pages 2156-2164Publisher
TSINGHUA UNIV PRESS
DOI: 10.1007/s12274-020-2824-7
Keywords
antibacterial nanomaterials; nanozyme; multidrug-resistant bacteria; wound healing
Categories
Funding
- National Natural Science Foundation of China [81972080, 81902198]
- China Postdoctoral Science Foundation [2018M640776, 2019M662980, BX20190150]
- Natural Science Foundation of Guangdong Province [2015A30312004, 2020A1515010398]
- Science and Technology Planning Project of Guangdong Province [2014A020215025, 2017B030314139]
- Medical Research Foundation of Guangdong Province [A2019228]
- Research Program of PLA [CGZ16C004]
- President Foundation of Zhujiang Hospital, Southern Medical University [yzjj2018rc09]
- Scientific Research Foundation of Southern Medical University [C1051353, PY2018N060]
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Antibacterial nanomaterials have attracted growing interest for bacterial infection therapy. However, most nanomaterials eliminate bacteria either physically or chemically, which hampers their efficacy when dealing with multidrug-resistant bacteria. To overcome this, we integrated copper sulfide (CuS) nanoparticles with active graphene oxide nanosheets (GO NSs) to synthesize a superior nanocomposite (CuS/GO NC) that acts both physically and chemically on the bacteria. CuS/GO NC was produced using a facile hydrothermal method, whereby the CuS nanoparticles grew and were uniformly dispersed on the GO NSs in situ. We found that the CuS/GO NC possesses a unique needle-like morphology that physically damages the bacterial cell membrane. CuS/GO NC also exhibits high oxidase- and peroxidase-like activity, ensuring efficient generation of the reactive oxygen species center dot OH from H2O2, which kills bacteria chemically. These features endow the CuS/GO NC with excellent antibacterial capabilities to kill multidrug-resistant bacteria such as methicillin-resistant Staphylococcus aureus (MRSA) with only a single dose. Additionally, it was found that the CuS/GO NC accelerated the healing of infected wounds in vivo owing to its good biocompatibility as well as facilitation of cell migration and collagen secretion. This study provides a new strategy to combine the physical and chemical antibacterial modes of nanomaterials to develop more effective therapies to combat multidrug-resistant bacterial infections.
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