Journal
NANO RESEARCH
Volume 13, Issue 3, Pages 795-801Publisher
TSINGHUA UNIV PRESS
DOI: 10.1007/s12274-020-2697-9
Keywords
CsPbBr3 nanocrystals; stress response encapsulation; cancer diagnose
Categories
Funding
- National Key Research and Development Program of China [2018YFE0208500]
- Major Research Plan of the National Natural Science Foundation of China [91963206]
- National Natural Science Foundation of China [U1508202, 51627810]
- Natural Science Foundation of Jiangsu Province [SBK2018022120]
- open fund of Wuhan National Laboratory for Optoelectronics [2018WNLOKF020]
- open fund of Jiangsu Key Laboratory of Electrochemical Energy Storage Technologies [EEST2018-1]
- civil aerospace technology preliminary research project of the State Administration of Science, Technology and Industry for National Defense
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Great photoelectric properties can herald the high potentials of CsPbBr3 nanocrystals (NCs) to function as the fluorescent probes for early tumor diagnosis. However, the intrinsic water vulnerability of CsPbBr3 NCs highly restricts their biomedical applications. To conquer this challenge, we herein introduce a nature inspired stress-response method to tightly encapsulate CsPbBr3 into SiO2 nano-shells that can dramatically improve the water stability of CsPbBr3@SiO2 nanoparticles for over 48 h. We further highlighted the advantageous features of CsPbBr3@SiO2 by using them as the fluorescent probes for CT26 tumor cell imaging with their high water stability, biocompatibility, and low cytotoxicity. Our work for the first time exhibited the potential of lead halide perovskite NCs for tumor diagnosis, and can highly anticipate the further in vivo biomedical applications that light up live cells.
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