Journal
NANO LETTERS
Volume 20, Issue 6, Pages 4306-4311Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.nanolett.0c00990
Keywords
DNA nanotechnology; lipid membranes; synthetic ion channel; dodecane; lipid flipping; molecular dynamics
Categories
Funding
- ERC [DesignerPores 647144]
- Winton Programme for the Physics of Sustainability
- Cambridge Trust Vice Chancellor's Award
- Engineering and Physical Sciences Research Council (EPSRC)
- National Science Foundation (USA) [DMR-1827346]
- National Institutes of Health [P41-GM104601]
- XSEDE allocation grant [MCA05S028]
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Lipid membranes, enveloping all living systems, are of crucial importance, and control over their structure and composition is a highly desirable functionality of artificial structures. However, the rational design of protein-inspired systems is still challenging. Here we have developed a highly functional nucleic acid construct that self-assembles and inserts into membranes, enabling lipid transfer between inner and outer leaflets. By designing the structure to account for interactions between the DNA, its hydrophobic modifications, and the lipids, we successfully exerted control over the rate of interleaflet lipid transfer induced by our DNA-based enzyme. Furthermore, we can regulate the level of lipid transfer by altering the concentration of divalent ions, similar to stimuli-responsive lipid-flipping proteins.
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