Journal
NANO LETTERS
Volume 20, Issue 5, Pages 3079-3089Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.nanolett.9b05035
Keywords
Rhodium nanozyme; anti-inflammatory effect; theranostics; colon cancer; RONS scavenging
Categories
Funding
- National Natural Science Foundation of China [31800834]
- National Key Research and Development Program [2018YFA0704003]
- Natural Science Foundation of Guangdong [2018B030308003, 2018A0303130273, 2016A030313324]
- Basic Research Program of Shenzhen [JCYJ20170412111100742, JCYJ20160422091238319]
- University Synergy Innovation Program of Anhui Province [GXXT-2019-045]
- Fundamental Research Funds for the Central Universities [JZ2020HGTB0031, JZ2018HGPA0273]
- Tip-top Scientific and Technical Innovative Youth Talents of Guangdong Special Support Program [2015TQ01R510]
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Colitis-associated colorectal cancer (CAC), in which chronic inflammation is a well-recognized carcinogen, requires concurrent anti-inflammation and antitumor treatments in the clinic. Herein, we report polyethylene glycol (PEG)-coated (PEGylated) ultrasmall rhodium nanodots (Rh-PEG NDs) can serve as a metallic nanozyme with reactive oxygen and nitrogen species (RONS) scavenging properties as well as photothermal activities for anti-inflammation and antitumor theranostics in colon diseases. Benefiting from multienzyme activities against RONS, Rh-PEG NDs can decrease the levels of pro-inflammatory cytokines (TNF-alpha, IL-6), resulting in good anti-inflammatory effect on dextran sulfate sodiuminduced colitis. By virtue of high photothermal conversion efficiency (48.9%), Rh-PEG NDs demonstrate complete ablation of CT-26 colon tumor without any recurrence. Most importantly, Rh-PEG NDs exhibit good biocompatibility both at the cellular and animal levels. Our findings provide a paradigm to utilize metallic nanozymes for the potential management of colon diseases.
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