Journal
NANO LETTERS
Volume 20, Issue 4, Pages 2522-2529Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.nanolett.9b05267
Keywords
photothermal therapy (PTT); T-1-MRI; magnetic resonance temperature imaging (MRTI); temperature monitoring
Categories
Funding
- National Funds for Distinguished Young Scientists [51725202]
- Key Project of the Shanghai Science and Technology Commission [19JC1412000]
- National Natural Science Foundation of China [51872094, 81971583]
- National Science Foundation for the Young Scientists of China [51702211, 21805090]
- Shanghai Municipal Science and Technology Major Project [2018SHZDZX01]
- Shanghai Natural Science Foundation [17ZR1401600]
- ZJLab [17ZR1401600]
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Photothermal therapy (PTT) is an efficient approach for cancer treatment. However, accurately monitoring the spatial distribution of photothermal transducing agents (PTAs) and mapping the real-time temperature change in tumor and peritumoral normal tissue remain a huge challenge. Here, we propose an innovative strategy to integrate T-1-MRI for precisely tracking PTAs with magnetic resonance temperature imaging (MRTI) for real-time monitoring temperature change in vivo during PTT. NaBiF4: Gd@PDA@PEG nanomaterials were synthesized with favorable T-1-weighted performance to target tumor and localize PTAs. The extremely weak susceptibility (1.04 X 10(-6) emu g(-1)Oe(1-)) of NaBiF4: Gd@PDA@PEG interferes with the local phase marginally, which maintains the capability of MRTI to dynamically record real-time temperature change in tumor and peritumoral normal tissue. The time resolution is 19 s per frame, and the detection precision of temperature change is approximately 0.1 K. The approach achieving PTT guided by multimode MRI holds significant potential for the clinical application.
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