Journal
NANO LETTERS
Volume 20, Issue 6, Pages 4211-4219Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.nanolett.0c00650
Keywords
Radiotherapy; Hypoxia; Angiogenesis; Erythrocytes; GOx
Categories
Funding
- National Natural Science Foundation of China [21874077]
- Key R&D projects of Jiangsu Province
- Science and Technology R&D Fund of Nantong City [JC2019139]
- Large Instruments Open Foundation of Nantong University
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Radiotherapy (RT) as one of the most powerful cancer treatment strategies has been greatly restricted by tumor hypoxia. A mounting effort has been devoted to develop oxygen delivery systems for boosting the RT effect. Unluckily, those systems only supplied modest oxygen, which could not afford more than once and long-time RT. Herein, we describe the development of a glucose-regulated drug release platform, allowing for a long-term tumor normoxic microenvironment and repeated RT for a long time. The repeated cycles resulted in sustained high Endostar plasma levels, which dramatically normalized the tumor vasculature and chronically reversed tumor hypoxia. Taking advantage of the inexhaustible supply of oxygen, Endo@GOx-ER enabled RT achieved an impressive cancer treatment output. To the best of our knowledge, our strategy is the initial attempt to overcome tumor-hypoxia-limited RT through the normalization of tumor vasculature by using an erythrocyte-inspired and glucose-activatable platform and it visually casts a light on the clinical development.
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