Journal
MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH
Volume 784, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.mrrev.2020.108309
Keywords
Telomere length; mtDNA(4977) common deletion; Mitochondria] damage; Aging; Coronary artery disease
Funding
- National Research Council (CNR) grant, Progetto di Interesse Invecchiamento
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Age is the dominant risk factor for the most prevalent atherosclerotic vascular diseases, including coronary artery disease, myocardial infarction, cerebrovascular disease and stroke. In human, telomere erosion and mitochondrial DNA (mtDNA) damage play a central role in the mechanisms leading to cellular aging decline. This review summarizes the most relevant findings on the role of telomere shortening and the common mtDNA(4977) deletion in the progression and evolution of atherosclerosis by combining insight from experimental models and human clinical studies. The current evidence shows a link between telomere erosion and compromised mitochondrial function and provides a new perspective regarding their potential role as clinical biomarkers and therapeutic targets. (C) 2020 Elsevier B.V. All rights reserved.
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