Journal
MOLECULES
Volume 25, Issue 11, Pages -Publisher
MDPI
DOI: 10.3390/molecules25112492
Keywords
peptides; inhibitory; metabolic syndrome; cytotoxic properties; antimicrobial activity
Funding
- Ministry of Science and Higher Education from the budget for science [IP2015 026174]
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The aim of this study was to determine the cytotoxic properties, influence on enzyme activity involved in metabolic syndrome, and antimicrobial activity of synthetic peptides with GQLGEHGGAGMG, GEHGGAGMGGGQFQPV, EQGFLPGPEESGR, RLARAGLAQ, YGNPVGGVGH, and GNPVGGVGHGTTGT sequences. Peptides have no cytotoxic effect on cells. The highest inhibitory effect on angiotensin converting enzyme I was noted for peptide GT-14 (IC50 = 525.63 mu g/mL). None of the tested peptides had an influence on alpha -glucosidase. The highest alpha -amylase and lipase inhibitory activity was noted for GG-12 (IC50 = 56.72 and 60.62 mu g/mL, respectively). The highest lipoxidase inhibitory activity was determined for peptide ER-13 (IC50 = 84.35 mu g/mL). Peptide RQ-9 was characterized by the highest COX inhibitory activity (0.31 and 4.77 mu g/mL for COX-1 and COX-2, respectively). Only peptide RQ-9 inhibited S. enteritidis ATCC 4931 growth (42-48%) in all tested concentrations (15.62-250 mg/mL).
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