Journal
MOLECULES
Volume 25, Issue 10, Pages -Publisher
MDPI
DOI: 10.3390/molecules25102364
Keywords
dibromocyclopropanation; CHBr3; Makosza reaction; phase-transfer catalysis; flow chemistry; unsaturated alcohols
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Dibromocyclopropanations are conventionally done by addition of dibromocarbene to alkenes under phase-transfer conditions in batch reactions using a strong base (50% NaOH (aq)), vigorous stirring and long reaction times. We have shown that cyclopropanation of unsaturated alcohols can be done under ambient conditions using continuous flow chemistry with 40% (w/w) NaOH (aq) as the base. The reactions were generally rapid; the yields were comparable to yields reported in the literature for the conventional batch reaction
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