Journal
MOLECULES
Volume 25, Issue 9, Pages -Publisher
MDPI
DOI: 10.3390/molecules25092022
Keywords
Sideritis sipylea Boiss; phytochemical profile; total phenolic content; tyrosinase; elastase; antioxidant activity; ultrasound-assisted extraction (UAE); supercritical fluid extraction (SFE); UPLC-HRMS; GC-MS
Funding
- European Union (ERDF)
- Greek national funds through the Operational Program Competitiveness, Entrepreneurship and Innovation, under the call STRENGTHENING RESEARCH AND INNOVATION INFRASTRUCTURES [5002803]
Ask authors/readers for more resources
Sideritis sipylea Boiss. is an endemic plant of the Mediterranean basin that is distributed in the Greek islands of the North Aegean Sea, i.e., Lesvos, Chios, Samos, and Ikaria, and in the West and Middle peninsula of Turkey. It is considered an endangered species because of its uncontrolled collection from its original habitat. Although the antioxidant, anti-inflammatory and antimicrobial properties have been previously reported, the total chemical profile has not yet been explored. In this context, the chemical profiles of the water/methanol (HA), methanol (ME), and ethyl acetate (EtOAc) extracts were analyzed using ultra-performance liquid chromatography coupled with high-resolution mass spectrometry (UPLC-HRMS). In parallel, analysis by gas chromatography-mass spectrometry (GC-MS) was employed for the dichloromethane extract (DCM) as well as for the essential oil (EO) and the extract obtained by supercritical fluid extraction (SFE). Furthermore, the total phenolic content (TPC) along with the in vitro tyrosinase and elastase enzyme inhibitory activity of different extracts was evaluated, towards the discovery of new active agents for cosmetic formulations. These activities are in accordance with its well-known antioxidant and anti-inflammatory properties, confirming the importance of ethnopharmacological references for S. sipylea in Greece and Turkey.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available