Journal
MOLECULES
Volume 25, Issue 8, Pages -Publisher
MDPI
DOI: 10.3390/molecules25081887
Keywords
porphyrin; metalloporphyrins; photodynamic therapy; Leishmania braziliensis; Leishmania panamensis; singlet oxygen
Funding
- COLCIENCIAS
- Universidad del Atlantico [002047, CB 22 TGI 2018]
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In this study, a family of porphyrins based on 5,10,15,20-Tetrakis(4-ethylphenyl)porphyrin (1, Ph) and six metallo-derivatives (Zn2+ (2, Ph-Zn), Sn4+ (3, Ph-Sn), Mn2+ (4, Ph-Mn), Ni2+ (5, Ph-Ni), Al3+ (6, Ph-Al), and V3+ (7, Ph-V)) were tested as photosensitizers for photodynamic therapy against Leishmania braziliensis and panamensis. The singlet oxygen quantum yield value (Phi(Delta)) for (1-7) was measured using 1,3-diphenylisobenzofuran (DPBF) as a singlet oxygen trapping agent and 5,10,15,20-(tetraphenyl)-porphyrin (H2TPP) as a reference standard; besides, parasite viability was estimated by the MTT assay. After metal insertion into the porphyrin core, the Phi(Delta) increased from 0.76-0.90 and cell viability changed considerably. The Phi(Delta) and metal type changed the cytotoxic activity. Finally, (2) showed both the highest Phi(Delta) (0.90) and the best photodynamic activity against the parasites studied (IC50 of 1.2 mu M).
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