Journal
MOLECULES
Volume 25, Issue 7, Pages -Publisher
MDPI
DOI: 10.3390/molecules25071607
Keywords
porphyrin; triazole; polyvinylpyrrolidone; photodynamic therapy; human bladder cancer cells; human retinal pigment epithelial cells
Funding
- University of Aveiro
- FCT/MCT [FCT UID/QUI/00062/2019, TDC/QEQQOR/1273/2012, UID/NEU/04539/2019 FCT UID/QUI/00062/2013]
- LAQV-REQUIMTE [UIDB/50006/2020]
- CQE unit [UIDB/00100/2020]
- COMPETE-FEDER [POCI-01-0145-FEDER-007440]
- Centro 2020 Regional Operational Programme: HEALTHYAGING 2020 [CENTRO-01-0145-FEDER-000012]
- FCT [SFRH/BPD/79521/2011]
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Novel triazole-porphyrin derivatives (TZ-PORs) were synthesized through the Heck reaction and then incorporated into polyvinylpyrrolidone (PVP) micelles. After verifying that this incorporation did not compromise the photophysical and chemical features of TZ-PORs as photosensitizers, the phototoxicity of the formulations towards cancer cells was screened. Biological studies show high photodynamic activity of all PVP-TZ-POR formulations against a bladder cancer cell line with a particular highlight to PVP-TZ-POR 7e and 7f that are able to significantly reduce HT-1376 cell viability, while they had no effect on control ARPE-19 cells.
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