Journal
MOLECULES
Volume 25, Issue 6, Pages -Publisher
MDPI
DOI: 10.3390/molecules25061389
Keywords
antimicrobial compounds; dendrimers; Ciprofloxacin
Funding
- Lundbeck foundation [2009-4618]
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Infections caused by bacteria resistant to antibiotics are an increasing problem. Multivalent antibiotics could be a solution. In the present study, a covalent conjugate between Ciprofloxacin and a G0-PAMAM dendrimer has been synthesized and tested against clinically relevant Gram-positive and Gram-negative bacteria. The conjugate has antimicrobial activity and there is a positive dendritic effect compared to Ciprofloxacin itself.
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