Journal
MOLECULAR PHARMACEUTICS
Volume 18, Issue 2, Pages 491-505Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.molpharmaceut.0c00154
Keywords
nanomedicine; nanoparticles; topical drug delivery; skin disorder
Funding
- Singapore Agency for Science, Technology and Research (A*STAR) Science and Engineering Research Council Additive Manufacturing for Biological Materials (AMBM) program [A18A8b0059]
- City University of Hong Kong [9610472]
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Topical drug delivery has advantages over other routes, but the stratum corneum poses a challenge. Nanotechnology offers opportunities to overcome this challenge with nanocarriers like liposomes and nanoparticles. These formulations show potential in treating skin disorders, with further developments needed.
Topical drug delivery has inherent advantages over other administration routes. However, the existence of stratum corneum limits the diffusion to small and lipophilic drugs. Fortunately, the advancement of nanotechnology brings along opportunities to address this challenge. Taking the unique features in size and surface chemistry, nanocarriers such as liposomes, polymeric nanoparticles, gold nanoparticles, and framework nucleic acids have been used to bring drugs across the skin barrier to epidermis and dermis layers. This article reviews the development of these formulations and focuses on their applications in the treatment of skin disorders such as acne, skin inflammation, skin infection, and wound healing. Existing hurdles and further developments are also discussed.
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