Journal
MOLECULAR NEUROBIOLOGY
Volume 57, Issue 6, Pages 2654-2670Publisher
SPRINGER
DOI: 10.1007/s12035-020-01911-8
Keywords
Estrogen; Alzheimer's disease; Estrogen signaling; Estrogen-related factors; Estrogen receptors; Estrogen-metabolizing enzymes
Categories
Funding
- Pharmakon Neuroscience Research Network, Dhaka, Bangladesh
Ask authors/readers for more resources
Estrogens play a crucial physiological function in the brain; however, debates exist concerning the role of estrogens in Alzheimer's disease (AD). Women during pre-, peri-, or menopause periods are more susceptible for developing AD, suggesting the connection of sex factors and a decreased estrogen signaling in AD pathogenesis. Yet, the underlying mechanism of estrogen-mediated neuroprotection is unclarified and is complicated by the existence of estrogen-related factors. Consequently, a deeper analysis of estrogen receptor (ER) expression and estrogen-metabolizing enzymes could interpret the importance of estrogen in age-linked cognitive alterations. Previous studies propose that hormone replacement therapy may attenuate AD onset in postmenopausal women, demonstrating that estrogen signaling is important for the development and progression of AD. For example, ER alpha exerts neuroprotection against AD by maintaining intracellular signaling cascades and study reported reduced expression of ER alpha in hippocampal neurons of AD patients. Similarly, reduced expression of ER beta in female AD patients has been associated with abnormal function in mitochondria and improved markers of oxidative stress. In this review, we discuss the critical interaction between estrogen signaling and AD. Moreover, we highlight the potential of targeting estrogen-related signaling for therapeutic intervention in AD.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available