Journal
MOLECULAR IMMUNOLOGY
Volume 121, Issue -, Pages 111-117Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.molimm.2020.02.015
Keywords
Monocytes; Dendritic cells; Microbial infection; Development; Innate immunity; PAMPs
Categories
Funding
- Deutsche Forschungsgemeinschaft [AU338/3-1, TR240 TPB09]
- European Social Fund in Baden-Wurttemberg
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The immune system protects from infections primarily by detecting and eliminating invading pathogens. This is predominantly mediated by innate immune cells like neutrophils, monocytes and dendritic cells (DCs) expressing specific receptors recognizing pathogen-associated molecular patterns. DC activation by pathogens leads to the initiation of antigen-specific adaptive immune responses, thereby bridging the innate and adaptive immune systems. However, various pathogens have evolved immune evasion strategies to ensure their survival. In this review, we highlight recent findings on how various microorganisms or their structural features affect or modulate DC development and whether this has any consequences for a protective immune response.
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