Journal
MOLECULAR GENETICS AND METABOLISM
Volume 130, Issue 4, Pages 230-238Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ymgme.2020.05.005
Keywords
Metabolomics; Metabolism; Acute myeloid leukemia; Glycolysis; TCA cycle; Oxidative phosphorylation; Isocitrate dehydrogenase
Funding
- American Society of Hematology Minority Medical Student Award Program
- Leukemia & Lymphoma Society Translational Research Program [6587-20]
- Cure Childhood Cancer
- Stanford SPARK program
- Jane Coffin Childs Memorial Fund for Medical Research
- Stanford Maternal and Child Health Research Institute
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Acute myeloid leukemia (AML) is a complex, heterogenous hematological malignancy caused by mutations in myeloid differentiation and proliferation. Response to therapy and long-term outcomes vary widely based on chromosomal and molecular aberrations. Many platforms have been used to characterize and stratify AML. Metabolomics, the global profiling of small molecules in a biological sample, has emerged in the last decade as an important tool for studying the metabolic dependency of cancer cells. Metabolic reprogramming is not only an important manifestation of AML but clinically relevant for diagnosis, risk stratification and targeted drug development. In this review, we discuss notable metabolic studies of the last decade and their application to novel therapies.
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