Journal
MOLECULAR DIVERSITY
Volume 25, Issue 1, Pages 323-332Publisher
SPRINGER
DOI: 10.1007/s11030-020-10092-4
Keywords
Porous polymer; Heterogeneous catalysis; Heterocycles; Condensation; Waste prevention
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Funding
- University of Malaya, Malaysia [NANOCAT RU001-2019]
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This study presents an efficient synthesis of 2-amino-4H-benzo[b]pyrans using mesoporous poly-melamine-formaldehyde as a polymeric heterogeneous catalyst. The reaction was conducted under green chemistry principles with good yields obtained. The research also suggests that porous organic polymers play a vital role in solid-phase synthesis.
This paper presents the efficient synthesis of 2-amino-4H-benzo[b]pyrans using mesoporous poly-melamine-formaldehyde as a polymeric heterogeneous catalyst. According to the principals of green chemistry, the reaction was performed by the planetary ball milling process at ambient and neat conditions. The heterogeneous catalyst could be reused up to five runs with no reducing of catalytic efficiency. A variety of substituted 2-amino-4H-benzo[b]pyrans were obtained in good to excellent yields under eco-friendly conditions. Other advantages of the current methodology include short reaction time, wide substrate-scope, and use of a metal-free polymeric catalyst. Also, the current method avoids the use of hazardous reagents and solvents, tedious workup and multi-step purification. This work revealed that porous organic polymers containing Lewis base sites having acceptor-donner hydrogen bonding functional groups, and high porosity could play a vital role in the promotion of the one-pot multicomponent reactions in the solid-phase synthesis. [GRAPHICS] .
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