Journal
MITOCHONDRION
Volume 52, Issue -, Pages 67-74Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.mito.2020.02.009
Keywords
Mitochondria; Nucleic acid nanoparticle; Nanoparticle formation; Nucleic acid release; Mitochondrial environment-response; Nucleic acid medicine
Categories
Funding
- Ministry of Education, Culture, Sports, Science and Technology [15595383, 17923708]
- Japanese Government (MEXT)
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The delivery of nucleic acids targeting mutant mtDNA represent a potential strategy for addressing a variety of mitochondria-related diseases. We previously developed a MITO-Porter, a nano carrier that is capable of delivering nanoparticles of nucleic acids to mitochondria of human cells. Here, we report on an investigation of a series of nanoparticles formed with various poly cationic peptides that can release nucleic acids in response to a mitochondrial environment. A significant relationship was found between the number of and the location of arginine and histidine residues in the peptide sequence and the release of nucleic acids in a mitochondrial environment.
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