Journal
MICROCHIMICA ACTA
Volume 187, Issue 5, Pages -Publisher
SPRINGER WIEN
DOI: 10.1007/s00604-020-04288-6
Keywords
Au@Ag@SiO2; Bimetallic core-shell nanoparticles; Molecularly imprinted polymer; Theobromine; Electrochemical determination
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Funding
- National Natural Science Foundation of China [61201091]
- Opening Fund of Key Lab of Marine Bioactive Substance and Modern Analytical Technique, SOA [MBSMAT-2018-03]
- Key Scientific Research Project of Colleges and Universities in Henan Province [20B150022]
- Nanhu Scholars Program for Young Scholars of XYNU
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A highly uniform and monodisperse silica-encapsulated Au@Ag multilayered core-shell nanorods (similar to 80 nm in length) has been prepared with excellent electrocatalytic properties. Using the Au@Ag@SiO2 nanoassemblies to substantially enhance the sensitivity and the sol-gel molecularly imprinted polymer (MIP) with imprinted cavities to present special molecular recognition sites, a novel electrochemical sensing platform was rationally designed, fabricated, and tested for efficient theobromine (THB) quantification. The formation of final Au@Ag@SiO2@MIP was characterized by transmission electron microscopy, X-ray photoelectron spectroscopy, Fourier transform infrared spectroscopy, cyclic voltammetry, and electrochemical impedance spectroscopy. The performance of the Au@Ag@SiO2@MIP modified electrode was evaluated by differential pulse voltammetry with the changes in peak current of hexacyanoferrate redox probe measured at a working potential of 0.2 V (vs. saturated calomel electrode) as determination signal. Under optimal conditions, the quantitation of THB was attained in a broad linear range from 10 nM to 100 mu M with a detection limit of 8.0 nM. The selectivity of Au@Ag@SiO2@MIP was examined according to its recognition to THB and the interferents. Finally, the sensing platform was successfully applied to extract and determine THB from food, biological, and environmental samples with acceptable recoveries (92.20-107.1%) and relative standard deviation < 4%. The propsed sensor provides a robust means for monitoring alkaloids in complex matrices and a promising opportunity to develop sensitive and selective electrode materials with good reusability. Graphical abstract
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