Journal
MEDIATORS OF INFLAMMATION
Volume 2020, Issue -, Pages -Publisher
HINDAWI LTD
DOI: 10.1155/2020/7605160
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Funding
- National Nature Science Foundation of China [31872442]
- Graduate Innovation Fund of Jilin University [201910183730]
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Alzheimer's disease (AD) is a common neurodegenerative disease. A beta plays an important role in the pathogenesis of AD. Sodium butyrate (NaB) is a short-chain fatty acid salt that exerts neuroprotective effects such as anti-inflammatory, antioxidant, antiapoptotic, and cognitive improvement in central nervous system diseases. The aim of this study is to research the protective effects of NaB on neurons against A beta toxicity and to uncover the underlying mechanisms. The results showed that 2 mM NaB had a significant improvement effect on A beta-induced N2a cell injury, by increasing cell viability and reducing ROS to reduce injury. In addition, by acting on the GPR109A receptor, NaB regulates the expression of AD-related genes such as APP, NEP, and BDNF. Therefore, NaB protects N2a cells from A beta-induced cell damage through activating GPR109A, which provides an innovative idea for the treatment of AD.
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