Journal
MATRIX BIOLOGY
Volume 91-92, Issue -, Pages 109-116Publisher
ELSEVIER
DOI: 10.1016/j.matbio.2020.03.010
Keywords
fibroblast; myocardial infarction; wound healing; scar formation; inflammation
Categories
Funding
- National Institutes of Health [HL075360, HL129823, HL137319]
- Biomedical Laboratory Research and Development Service of the Veterans Affairs Office of Research and Development [5I01BX000505]
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Cardiac wound healing after myocardial infarction (MI) evolves from pro-inflammatory to anti-inflammatory to reparative responses, and the cardiac fibroblast is a central player during the entire transition. The fibroblast mirrors changes seen in the left ventricle infarct by undergoing a continuum of polarization phenotypes that follow pro-inflammatory, anti-inflammatory, and pro-scar producing profiles. The development of each pheno-type transition is contingent upon the MI environment into which the fibroblast enters. In this mini-review, we summarize our current knowledge regarding cardiac fibroblast activation during MI and highlight key areas where gaps remain. (c) 2020 The Author(s). Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license. (http://creativecommons.org/licenses/by-nc-nd/4.0/)
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