Journal
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
Volume 109, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.msec.2019.110481
Keywords
Calcium phosphate cement; Manganese; Osteogenic differentiation; Adhesion
Categories
Funding
- National Key R&D Program of China [2016YFB0700803]
- National Natural Science Foundation of China [31800791, 51672087]
- Guangzhou Science and Technology Program of China [201508020017]
- Fundamental Research Funds for the Central Universities
- Natural Science Foundation of Guangdong Province [2018030310062]
- China Postdoctoral Science Foundation [2016M602601, 2018T110926]
- Scientific and Technological Plan of Guangdong Province [2017B030314139]
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Lack of osteogenic capacity limits the bone repair effect of calcium phosphate cement (CPC). In present work, bivalent manganese ion (Mn2+) doped beta-tricalcium phosphate (Mn-TCP) was incorporated into CPC to enhance its osteogenic ability. The incorporation of Mn-TCP promoted the hydration reaction of CPC. The presence of Mn2+ made the hydration products finer. When adding 10 wt% Mn-TCP in CPC (Mn-CPC-1), the setting time of CPC was shortened, whereas the strength and injectability were not changed. Mouse Bone marrow mesenchymal stem cells (mBMSCs) on Mn-CPC-1 and CPC with 20 wt% Mn-TCP (Mn-CPC-2) presented better adhesion and spreading behaviors. Besides, Mn-CPC-1 promoted the gene levels of ALP, Col-I and OC while Mn-CPC-2 promoted the gene levels of Runx2 and OC. Cellular behaviors were related to two points: one was the increase of adsorption capacity of proteins (e.g. BSA) after changing the surface properties of bone cements; and the other was the biological role of Mn2+ released from CPC in osteogenesis. All the results indicated that CPC incorporated with 10 wt% Mn-TCP has good osteogenesis and proper physicochemical properties, which will be a prospective biomaterial applying in the area of bone regeneration.
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