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MOLECULAR AND BIOCHEMICAL PARASITOLOGY (2013)
Folate metabolism in human malaria parasites-75 years on
Ingrid B. Mueller et al.
MOLECULAR AND BIOCHEMICAL PARASITOLOGY (2013)
Clinical features, diagnosis, and treatment of human African trypanosomiasis (sleeping sickness)
Peter G. E. Kennedy
LANCET NEUROLOGY (2013)
Evaluation of bioluminescence-based assays of anti-malarial drug activity
Sandra Hasenkamp et al.
MALARIA JOURNAL (2013)
Synthesis of Marine α-Methoxylated Fatty Acid Analogs that Effectively Inhibit the Topoisomerase IB from Leishmania donovani with a Mechanism Different from that of Camptothecin
Nestor M. Carballeira et al.
MARINE DRUGS (2013)
Eleganolone, a Diterpene from the French Marine Alga Bifurcaria bifurcata Inhibits Growth of the Human Pathogens Trypanosoma brucei and Plasmodium falciparum
Jean-Baptiste Galle et al.
MARINE DRUGS (2013)
Matching the power of high throughput screening to the chemical diversity of natural products
Curtis J. Henrich et al.
NATURAL PRODUCT REPORTS (2013)
Malaria biology and disease pathogenesis: insights for new treatments
Louis H. Miller et al.
NATURE MEDICINE (2013)
TECHNIQUES & APPLICATIONS A new tool for liver-stage malaria
Christina Tobin Kahrstroem
NATURE REVIEWS MICROBIOLOGY (2013)
Stage-Regulated GFP Expression in Trypanosoma cruzi: Applications from Host-Parasite Interactions to Drug Screening
Rafael Luis Kessler et al.
PLOS ONE (2013)
Aquaporin 2 Mutations in Trypanosoma brucei gambiense Field Isolates Correlate with Decreased Susceptibility to Pentamidine and Melarsoprol
Fabrice E. Graf et al.
PLOS NEGLECTED TROPICAL DISEASES (2013)
Chemotherapy for second-stage Human African trypanosomiasis
Vittoria Lutje et al.
COCHRANE DATABASE OF SYSTEMATIC REVIEWS (2013)
Flow cytometric enumeration of Plasmodium berghei-infected red blood cells stained with SYBR Green I
Voravuth Somsak et al.
ACTA TROPICA (2012)
Indotecan (LMP400) and AM13-55: Two Novel Indenoisoquinolines Show Potential for Treating Visceral Leishmaniasis
Rafael Balana-Fouce et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2012)
In Vitro Activity of Fluorescent Dyes against Asexual Blood Stages of Plasmodium falciparum
Fanny Joanny et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2012)
Validating a Firefly Luciferase-Based High-Throughput Screening Assay for Antimalarial Drug Discovery
Pulin Che et al.
ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES (2012)
2-Alkynoic fatty acids inhibit topoisomerase IB from Leishmania donovani
Nestor M. Carballeira et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2012)
High content live cell imaging for the discovery of new antimalarial marine natural products
Serena Cervantes et al.
BMC INFECTIOUS DISEASES (2012)
Global Phenotypic Screening for Antimalarials
W. Armand Guiguemde et al.
CHEMISTRY & BIOLOGY (2012)
Whole-cell in vitro screening for gametocytocidal compounds
Leonardo Lucantoni et al.
FUTURE MEDICINAL CHEMISTRY (2012)
Chronic Chagas' heart disease: a disease on its way to becoming a worldwide health problem: epidemiology, etiopathology, treatment, pathogenesis and laboratory medicine
Silvia Gilka Munoz-Saravia et al.
HEART FAILURE REVIEWS (2012)
Visceral Leishmaniasis
Johan van Griensven et al.
INFECTIOUS DISEASE CLINICS OF NORTH AMERICA (2012)
Adaptation of High-Throughput Screening in Drug Discovery-Toxicological Screening Tests
Pawel Szymanski et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2012)
Miltefosine: a review of its pharmacology and therapeutic efficacy in the treatment of leishmaniasis
Thomas P. C. Dorlo et al.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2012)
Drug Screen Targeted at Plasmodium Liver Stages Identifies a Potent Multistage Antimalarial Drug
Filipa P. da Cruz et al.
JOURNAL OF INFECTIOUS DISEASES (2012)
Discovery of a Novel Class of Orally Active Trypanocidal N-Myristoyltransferase Inhibitors
Stephen Brand et al.
JOURNAL OF MEDICINAL CHEMISTRY (2012)
The discovery and development of brentuximab vedotin for use in relapsed Hodgkin lymphoma and systemic anaplastic large cell lymphoma
Peter D. Senter et al.
NATURE BIOTECHNOLOGY (2012)
Leishmaniasis Worldwide and Global Estimates of Its Incidence
Jorge Alvar et al.
PLOS ONE (2012)
Dolabelladienetriol, a Compound from Dictyota pfaffii Algae, Inhibits the Infection by Leishmania amazonensis
Deivid Costa Soares et al.
PLOS NEGLECTED TROPICAL DISEASES (2012)
Untreated Human Infections by Trypanosoma brucei gambiense Are Not 100% Fatal
Vincent Jamonneau et al.
PLOS NEGLECTED TROPICAL DISEASES (2012)
Recent developments in sterol 14-demethylase inhibitors for Chagas disease
Frederick S. Buckner et al.
INTERNATIONAL JOURNAL FOR PARASITOLOGY-DRUGS AND DRUG RESISTANCE (2012)
Visceral leishmaniasis treatment: What do we have, what do we need and how to deliver it?
Lucio H. Freitas-Junior et al.
INTERNATIONAL JOURNAL FOR PARASITOLOGY-DRUGS AND DRUG RESISTANCE (2012)
Antitrypanosomal Activity of Fexinidazole, a New Oral Nitroimidazole Drug Candidate for Treatment of Sleeping Sickness
Marcel Kaiser et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2011)
Quantitative proteome profiling informs on phenotypic traits that adapt Leishmania donovani for axenic and intracellular proliferation
Pascale Pescher et al.
CELLULAR MICROBIOLOGY (2011)
First total synthesis and antileishmanial activity of (Z)-16-methyl-11-heptadecenoic acid, a new marine fatty acid from the sponge Dragmaxia undata
Nestor M. Carballeira et al.
CHEMISTRY AND PHYSICS OF LIPIDS (2011)
Identification of Inhibitors of the Leishmania cdc2-Related Protein Kinase CRK3
Laura A. T. Cleghorn et al.
CHEMMEDCHEM (2011)
Trypanocidal Activity of Nitroaromatic Prodrugs: Current Treatments and Future Perspectives
Shane R. Wilkinson et al.
CURRENT TOPICS IN MEDICINAL CHEMISTRY (2011)
Folate metabolic pathways in Leishmania
Tim J. Vickers et al.
ESSAYS IN BIOCHEMISTRY: MOLECULAR PARASITOLOGY (2011)
Fucoidan cures infection with both antimony-susceptible and -resistant strains of Leishmania donovani through Th1 response and macrophage-derived oxidants
Susanta Kar et al.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2011)
A High-Throughput Screen Targeting Malaria Transmission Stages Opens New Avenues for Drug Development
Kathrin Buchholz et al.
JOURNAL OF INFECTIOUS DISEASES (2011)
Review of the clinical pharmacokinetics of artesunate and its active metabolite dihydroartemisinin following intravenous, intramuscular, oral or rectal administration
Carrie A. Morris et al.
MALARIA JOURNAL (2011)
4-Acetoxydolastane Diterpene from the Brazilian Brown Alga Canistrocarpus cervicornis as Antileishmanial Agent
Adriana Oliveira dos Santos et al.
MARINE DRUGS (2011)
Kinase Inhibitors from Marine Sponges
Danielle Skropeta et al.
MARINE DRUGS (2011)
Anti-malarial, anti-algal, anti-tubercular, anti-bacterial, anti-photosynthetic, and anti-fouling activity of diterpene and diterpene isonitriles from the tropical marine sponge Cymbastela hooperi
Anthony D. Wright et al.
ORGANIC & BIOMOLECULAR CHEMISTRY (2011)
Antileishmanial Sesquiterpenes from the Brazilian Red Alga Laurencia dendroidea
Fernanda Lacerda da Silva Machado et al.
PLANTA MEDICA (2011)
Identification of Small Molecule Lead Compounds for Visceral Leishmaniasis Using a Novel Ex Vivo Splenic Explant Model System
Yaneth Osorio et al.
PLOS NEGLECTED TROPICAL DISEASES (2011)
Noninvasive biophotonic imaging for studies of infectious disease
Nuria Andreu et al.
FEMS MICROBIOLOGY REVIEWS (2011)
Discovery of Potent Small-Molecule Inhibitors of Multidrug-Resistant Plasmodium falciparum Using a Novel Miniaturized High-Throughput Luciferase-Based Assay
Edinson Lucumi et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2010)
2-Hexadecynoic acid inhibits plasmodial FAS-II enzymes and arrests erythrocytic and liver stage Plasmodium infections
Deniz Tasdemir et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2010)
Clinical aspects of hemolysis in patients with P-vivax malaria treated with primaquine, in the Brazilian Amazon
Wilson M. Ramos Junior et al.
BRAZILIAN JOURNAL OF INFECTIOUS DISEASES (2010)
Antiprotozoal Steroidal Saponins from the Marine Sponge Pandaros acanthifolium
Erik L. Regalado et al.
JOURNAL OF NATURAL PRODUCTS (2010)
Effect of Elatol, Isolated from Red Seaweed Laurencia dendroidea, on Leishmania amazonensis
Adriana Oliveira dos Santos et al.
MARINE DRUGS (2010)
Inhibitory Activity of Marine Sponge-Derived Natural Products against Parasitic Protozoa
Ilkay Orhan et al.
MARINE DRUGS (2010)
Single-Dose Liposomal Amphotericin B for Visceral Leishmaniasis in India
Shyam Sundar et al.
NEW ENGLAND JOURNAL OF MEDICINE (2010)
Chemotherapy against human African trypanosomiasis: Is there a road to success?
Christian Burri
PARASITOLOGY (2010)
Establishment of an In Vitro Assay for Assessing the Effects of Drugs on the Liver Stages of Plasmodium vivax Malaria
Rana Chattopadhyay et al.
PLOS ONE (2010)
The first total synthesis of the (±)-17-methyl-trans-4,5-methyleneoctadecanoic acid and related analogs with antileishmanial activity
Nestor M. Carballeira et al.
TETRAHEDRON LETTERS (2010)
Antimony Toxicity
Shyam Sundar et al.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH (2010)
NECT Is Next: Implementing the New Drug Combination Therapy for Trypanosoma brucei gambiense Sleeping Sickness
Oliver Yun et al.
PLOS NEGLECTED TROPICAL DISEASES (2010)
Assessment of Malaria In Vitro Drug Combination Screening and Mixed-Strain Infections Using the Malaria Sybr Green I-Based Fluorescence Assay
Edgie-Mark A. Co et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2009)
High-content live cell imaging with RNA probes: advancements in high-throughput antimalarial drug discovery
Serena Cervantes et al.
BMC CELL BIOLOGY (2009)
Transgenic Leishmania donovani clinical isolates expressing green fluorescent protein constitutively for rapid and reliable ex vivo drug screening
Nasib Singh et al.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2009)
Nifurtimox-eflornithine combination therapy for second-stage African Trypanosoma brucei gambiense trypanosomiasis: a multicentre, randomised, phase III, non-inferiority trial
Gerardo Priotto et al.
LANCET (2009)
Dissecting the essentiality of the bifunctional trypanothione synthetase-amidase in Trypanosoma brucei using chemical and genetic methods
Susan Wyllie et al.
MOLECULAR MICROBIOLOGY (2009)
Pentavalent Antimonials: New Perspectives for Old Drugs
Frederic Frezard et al.
MOLECULES (2009)
Total Synthesis and Antileishmanial Activity of the Natural Occurring Acetylenic Fatty Acids 6-Heptadecynoic Acid and 6-Icosynoic Acid
Nestor M. Carballeira et al.
LIPIDS (2009)
A comparative study of a flow-cytometry-based assessment of in vitro Plasmodium falciparum drug sensitivity
Stephan Karl et al.
MALARIA JOURNAL (2009)
Pharmacokinetic and Toxicological Profile of Artemisinin Compounds: An Update
Bikash Medhi et al.
PHARMACOLOGY (2009)
Imaging Leishmania development in their host cells
Thierry Lang et al.
TRENDS IN PARASITOLOGY (2009)
Reporter genes facilitating discovery of drugs targeting protozoan parasites
Anuradha Dube et al.
TRENDS IN PARASITOLOGY (2009)
Murine Models for Trypanosoma brucei gambiense Disease Progression-From Silent to Chronic Infections and Early Brain Tropism
Christiane Giroud et al.
PLOS NEGLECTED TROPICAL DISEASES (2009)
Artemisinin-based combination therapy for treating uncomplicated malaria
David Sinclair et al.
COCHRANE DATABASE OF SYSTEMATIC REVIEWS (2009)
Plasmodium falciparum:: Development of a transgenic line for screening antimalarials using firefly luciferase as the reporter
Long Cui et al.
EXPERIMENTAL PARASITOLOGY (2008)
Kinetic studies and bioactivity of potential manzamine prodrugs
Abbas Gholipour Shilabin et al.
JOURNAL OF NATURAL PRODUCTS (2008)
Chemical and genetic validation of dihydrofolate reductase-thymidylate synthase as a drug target in African trypanosomes
Natasha Sienkiewicz et al.
MOLECULAR MICROBIOLOGY (2008)
Antiprotozoan activity of Brazilian marine cnidarian extracts and of a modified steroid from the octocoral Carijoa riisei
Juliana Quero Reimao et al.
PARASITOLOGY RESEARCH (2008)
A mechanism for cross-resistance to nifurtimox and benznidazole in trypanosomes
Shane R. Wilkinson et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Performance and reliability of the SYBR Green I based assay for the routine monitoring or susceptibility of Plasmodium falciparum clinical associates
Marie Ange Rason et al.
TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE (2008)
The Natural Progression of Gambiense Sleeping Sickness: What Is the Evidence?
Francesco Checchi et al.
PLOS NEGLECTED TROPICAL DISEASES (2008)
Macrophage and T-Cell Gene Expression in a Model of Early Infection with the Protozoan Leishmania chagasi
Nicholas A. Ettinger et al.
PLOS NEGLECTED TROPICAL DISEASES (2008)
Human African trypanosomiasis: pharmacological re-engagement with a neglected disease
M. P. Barrett et al.
BRITISH JOURNAL OF PHARMACOLOGY (2007)
Target assessment for antiparasitic drug discovery
Julie A. Frearson et al.
TRENDS IN PARASITOLOGY (2007)
Treatment of Kala-Azar in southern Sudan using a 17-day regimen of sodium stibogluconate combined with paromomycin: A retrospective comparison with 30-day sodium stibogluconate monotherapy
Yosef Melaku et al.
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE (2007)
Injectable paromomycin for visceral leishmaniasis in India
Shyam Sundar et al.
NEW ENGLAND JOURNAL OF MEDICINE (2007)
Relapses of Plasmodium vivax infection usually result from activation of heterologous hypnozoites
Mallika Imwong et al.
JOURNAL OF INFECTIOUS DISEASES (2007)
Safety and toxicity of sulfadoxine/pyrimethamine - Implications for malaria prevention in pregnancy using intermittent preventive treatment
Philip J. Peters et al.
DRUG SAFETY (2007)
Cutaneous leishmaniasis
Richard Reithinger et al.
LANCET INFECTIOUS DISEASES (2007)
S-adenosylmethionine in protozoan parasites: Functions, synthesis and regulation
Rosa M. Reguera et al.
MOLECULAR AND BIOCHEMICAL PARASITOLOGY (2007)
Targeting atypical trypanosomatid DNA topoisomerase I
Rafael Balana-Fouce et al.
DRUG DISCOVERY TODAY (2006)
Toxic side effects of drugs used to treat Chagas' disease (American trypanosomiasis)
Jose A. Castro et al.
HUMAN & EXPERIMENTAL TOXICOLOGY (2006)
Antimalarial potential of xestoquinone, a protein kinase inhibitor isolated from a Vanuatu marine sponge Xestospongia sp.
Dominique Laurent et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2006)
Regulation of ornithine decarboxylase
Anthony E. Pegg
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
New approach for high-throughput screening of drug activity on Plasmodium liver stages
A Gego et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2006)
DNA binding properties of 9-substituted harmine derivatives
RH Cao et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2005)
Use of Leishmania donovani field isolates expressing the luciferase reporter gene in in vitro drug screening
Ashutosh et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2005)
High-throughput screening for potent and selective inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase
J Baldwin et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Effectiveness of a 10-day melarsoprol schedule for the treatment of late-stage human African trypanosomiasis: Confirmation from a multinational study (IMPAMEL II)
C Schmid et al.
JOURNAL OF INFECTIOUS DISEASES (2005)
Targeting the hemozoin synthesis pathway for new antimalarial drug discovery:: Technologies for in vitro β-hematin formation assay
BL Tekwani et al.
COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING (2005)
Possible mechanism of miltefosine-mediated death of Leishmania donovani
NK Verma et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2004)
RNA interference of Trypanosoma brucei topoisomerase IB:: both subunits are essential
RP Bakshi et al.
MOLECULAR AND BIOCHEMICAL PARASITOLOGY (2004)
New manzamine alkaloids from an indo-pacific sponge. Pharmacokinetics, oral availability, and the significant activity of several manzamines against HIV-I, AIDS opportunistic infections, and inflammatory diseases
M Yousaf et al.
JOURNAL OF MEDICINAL CHEMISTRY (2004)
Novel, rapid, and inexpensive cell-based quantification of antimalarial drug efficacy
TN Bennett et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2004)
Comparison of noninvasive fluorescent and bioluminescent small animal optical imaging
G Choy et al.
BIOTECHNIQUES (2003)
Mechanisms of arsenical and diamidine uptake and resistance in Trypanosoma brucei
E Matovu et al.
EUKARYOTIC CELL (2003)
Eflornithine for the treatment of human African trypanosomiasis
C Burri et al.
PARASITOLOGY RESEARCH (2003)
Turnover of trypanosomal ornithine decarboxylases
L Persson et al.
BIOCHEMICAL SOCIETY TRANSACTIONS (2003)
Myristoyl-CoA:protein N-myristoyltransferase, an essential enzyme and potential drug target in kinetoplastid parasites
HP Price et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Post-kala-azar dermal leishmaniasis
EE Zijistra et al.
LANCET INFECTIOUS DISEASES (2003)
Neuro-inflammatory risk factors for treatment failure in early second stage sleeping sickness patients treated with Pentamidine
V Lejon et al.
JOURNAL OF NEUROIMMUNOLOGY (2003)
Artemisinin: mechanisms of action, resistance and toxicity
SR Meshnick
INTERNATIONAL JOURNAL FOR PARASITOLOGY (2002)
Evidence for a non-LDL-mediated entry route for the trypanocidal drug suramin in Trypanosoma brucei
A Pal et al.
MOLECULAR AND BIOCHEMICAL PARASITOLOGY (2002)
Amphotericin B nephrotoxicity
G Deray
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2002)
Polyamine Metabolism as Chemotherapeutic Target in Protozoan Parasites
C. J. Bacchi et al.
MINI-REVIEWS IN MEDICINAL CHEMISTRY (2002)
Clinical description of encephalopathic syndromes and risk factors for their occurrence and outcome during melarsoprol treatment of human African trypanosomiasis
J Blum et al.
TROPICAL MEDICINE & INTERNATIONAL HEALTH (2001)
Marine organisms as a source of new anticancer agents
Gilberto Schwartsmann et al.
LANCET ONCOLOGY (2001)
Inhibition of heme detoxification processes underlies the antimalarial activity of terpene isonitrile compounds from marine sponges
AD Wright et al.
JOURNAL OF MEDICINAL CHEMISTRY (2001)
Novel intracellular SbV reducing activity correlates with antimony susceptibility in Leishmania donovani
P Shaked-Mishan et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Episomal and stable expression of the luciferase reporter gene for quantifying Leishmania spp. infections in macrophages and in animal models
G Roy et al.
MOLECULAR AND BIOCHEMICAL PARASITOLOGY (2000)
In vivo antimalarial activity of the beta-carboline alkaloid manzamine A
KKH Ang et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2000)
Targeted integration into a rRNA locus results in uniform and high level expression of transgenes in Leishmania amastigotes
A Misslitz et al.
MOLECULAR AND BIOCHEMICAL PARASITOLOGY (2000)