Journal
MAGNETIC RESONANCE IN CHEMISTRY
Volume 58, Issue 8, Pages 733-744Publisher
WILEY
DOI: 10.1002/mrc.5027
Keywords
quantitative NMR; H-2 deuterium observe; calibration standard; tube volume variation
Ask authors/readers for more resources
Tube to tube volume difference presents a challenge in obtaining correct external standard quantitative NMR (esqNMR) results. Deuterium (H-2) NMR is easily observable, intrinsically quantitative, present in all samples, free of interfering signals, and insensitive to probe tune/match and sample saltiness. These properties make(2)H peak integral an ideal parameter in esqNMR for correcting volume differences between the reference standard and analyte. We demonstrate a novel and practical technique abbreviated as H-2 SOLCOR (H-2 SOLvent CORrected), where the(2)H peak integral from the solvent is used as a universal internal standard to correct volume variations in NMR tubes, thereby improving accuracy and precision of esqNMR method. Herein, this simple yet effective technique is described, and practical considerations for successful implementation are presented.H-2 SOLCOR can be applied anywhere esqNMR is used, including where precious samples need to be accurately quantified for qualification as an authentic analytical standard.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available