Journal
KAOHSIUNG JOURNAL OF MEDICAL SCIENCES
Volume 36, Issue 8, Pages 640-648Publisher
WILEY
DOI: 10.1002/kjm2.12208
Keywords
breast cancer; EMI2(FBXO43); metastasis
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Funding
- Kaohsiung Medical University [KMU-TC108A04]
- National Chiao Tung University [NCTUKMU108-DR-01]
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Early mitotic inhibitor 2 (EMI2, gene symbolFBXO43), an APC/C inhibitor regulated by Plx1, is essential for cytostatic factor (CSF) activity. It belongs to subclass FBXO of the F-box proteins family. The aim of this study is to examine the clinicopathological significance of EMI2 in breast cancer. In this study, immunohistochemistry analysis was used to evaluate EMI2 expression in breast cancer tissues and then the association between EMI2 expression and clinicopathological factors was examined. Correlation of EMI2 with patient survival was analyzed by Kaplan-Meier survival curves. Among 192 patients analyzed, 105 (54.7%) had high expression of EMI2, and this was significantly associated with shortened disease free survival and overall survival in breast cancer patients. EMI2 expression was significantly associated with tumor grade (P= .006), tumor size (P< .001), and lymph node metastasis (P= .008). However, there was no significant correlation between EMI2 status and other biomarkers including ER, PR and Her2 status. Our results revealed that elevated EMI2 expression is a risk factor (hazard ratio = 3.93) for breast cancer and overexpression of EMI2 in breast cancer predicts higher risk of metastasis and worse survival. Therefore, EMI2 may be a potential therapeutic target for breast cancer.
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