4.3 Article

Cellular toxicological characterization of a thioxolated arsenic-containing hydrocarbon

Journal

Publisher

ELSEVIER GMBH
DOI: 10.1016/j.jtemb.2020.126563

Keywords

Arsenolipids; Arsenic-containing hydrocarbon; thioxo-AsHC 348; Liver cells; Oxidative stress; Genotoxicity

Funding

  1. German Research Foundation (DFG) [SCHW 903/10-1]
  2. Austrian Science Fund (FWF) [I2412-B21]
  3. Austrian Science Fund (FWF) [I2412] Funding Source: Austrian Science Fund (FWF)

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Arsenolipids, especially arsenic-containing hydrocarbons (AsHC), are an emerging class of seafood originating contaminants. Here we toxicologically characterize a recently identified oxo-AsHC 332 metabolite, thioxo-AsHC 348 in cultured human liver (HepG2) cells. Compared to results of previous studies of the parent compound oxo-AsHC 332, thioxo-AsHC 348 substantially affected cell viability in the same concentration range but exerted about 10-fold lower cellular bioavailability. Similar to oxo-AsHC 332, thioxo-AsHC 348 did not substantially induce oxidative stress nor DNA damage. Moreover, in contrast to oxo-AsHC 332 mitochondria seem not to be a primary subcellular toxicity target for thioxo-AsHC 348. This study indicates that thioxo-AsHC 348 is at least as toxic as its parent compound oxo-AsHC 332 but very likely acts via a different mode of toxic action, which still needs to be identified.

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