Journal
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
Volume 21, Issue 7, Pages 915-918Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jamda.2020.05.045
Keywords
COVID-19; coronavirus; older adults; mortality
Categories
Funding
- Centro de Investigacion Biomedica en Red de Enfermedades Cardiovasculares [CIBERCV CB16/11/00226-CB16/11/00420]
- national Spanish National Network for Biomedical Investigation on Cardiovascular Disease
Ask authors/readers for more resources
Objectives: Initial data on COVID-19 infection has pointed out a special vulnerability of older adults. Design: We performed a meta-analysis with available national reports on May 7, 2020 from China, Italy, Spain, United Kingdom, and New York State. Analyses were performed by a random effects model, and sensitivity analyses were performed for the identification of potential sources of heterogeneity. Setting and participants: COVID-19epositive patients reported in literature and national reports. Measures: All-cause mortality by age. Results: A total of 611,1583 subjects were analyzed and 141,745 (23.2%) were aged >= 80 years. The percentage of octogenarians was different in the 5 registries, the lowest being in China (3.2%) and the highest in the United Kingdom and New York State. The overall mortality rate was 12.10% and it varied widely between countries, the lowest being in China (3.1%) and the highest in the United Kingdom (20.8%) and New York State (20.99%). Mortality was <1.1% in patients aged <50 years and it increased exponentially after that age in the 5 national registries. As expected, the highest mortality rate was observed in patients aged >= 80 years. All age groups had significantly higher mortality compared with the immediately younger age group. The largest increase in mortality risk was observed in patients aged 60 to 69 years compared with those aged 50 to 59 years (odds ratio 3.13, 95% confidence interval 2.61-3.76). Conclusions and Implications: This meta-analysis with more than half million of COVID-19 patients from different countries highlights the determinant effect of age on mortality with the relevant thresholds on age >50 years and, especially, >60 years. Older adult patients should be prioritized in the implementation of preventive measures. (C) 2020 AMDA - The Society for Post-Acute and Long-Term Care Medicine.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available