Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 142, Issue 16, Pages 7334-7339Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jacs.0c02129
Keywords
-
Categories
Funding
- National Cancer Institute [U01-CA198989]
- University of Chicago Medicine Comprehensive Cancer Center [NIH CCSG: P30 CA014599]
- Division of Chemistry (CHE), National Science Foundation [NSF/CHE-1834750]
- Division of Materials Research (DMR), National Science Foundation [NSF/CHE-1834750]
- U.S. DOE [DE-AC02-06CH11357]
Ask authors/readers for more resources
Herein we report the design of a bacteriochlorin-based nanoscale metal-organic framework, Zr-TBB, for highly effective photodynamic therapy via both type I and type II mechanisms. The framework of Zr-TBB stabilizes 5,10,15,20-tetra(p-benzoato)bacteriochlorin (TBB) ligands toward oxygen and light via geometrical constraint. Upon 740 nm light irradiation, Zr-TBB efficiently generates various reactive oxygen species, including singlet oxygen, superoxide anion, hydrogen peroxide, and hydroxyl radicals, to afford superb antitumor efficacy on mouse models of breast and colon cancers, with cure rates of 40% and 60%, respectively.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available