Journal
CHEMICAL ENGINEERING JOURNAL
Volume 288, Issue -, Pages 648-658Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.cej.2015.12.047
Keywords
Electrospinning; Hybrid structure; Microfibers; Tissue engineering
Categories
Funding
- National Research Foundation of Korea - Ministry of Education, Science, and Technology (MEST) [NRF-2015R1A2A1A 15055305]
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Electrospinning has been widely used to fabricate micro/nano-sized fibers. However, use of three-dimensional (3D) scaffolds consisting only of electrospun micro/nanofibers has several limitations, such as inadequate mechanical properties and low pore-structure controllability. To overcome these challenges, we developed a new hybrid 3D scaffold, which was obtained by fusing two techniques: the conventional melt-plotting method and direct electrospinning writing (DE-writing). The macropores consisted of microsized struts in the hybrid scaffold were covered with size-controllable microfibrous mat obtained using direct electrospinning writing. By varying parameters of the direct electrospinning writing, such as the conical auxiliary electrode position, the width of the microfibrous mat on the melt-plotted structure could be controlled. This study proposes a new combinatory method of fabricating 3D hybrid scaffolds with reasonable mechanical properties and outstanding cellular activities consisting of melt-plotted struts with interlayered microfibrous mat. (C) 2015 Elsevier B.V. All rights reserved.
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