Journal
JOURNAL OF STATISTICAL MECHANICS-THEORY AND EXPERIMENT
Volume 2020, Issue 4, Pages -Publisher
IOP PUBLISHING LTD
DOI: 10.1088/1742-5468/ab7a1d
Keywords
molecular motors; exclusion processes
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Funding
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior-Brazil (CAPES) [001]
- Sao Paulo Research Foundation (FAPESP) [2017/20696-0, 2017/10555-0]
- Conselho Nacional de Desenvolvimento Cinetfico e Tecnologico (CNPq) [309239/2017-6]
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We present a stochastic model for programmed ribosomal -1 frameshift, triggered by a slippery sequence and a following pseudoknot on the mRNA template, that allows for the exact derivation of the stationary distribution of ribosome positions and for exact analytical calculations of the stationary rate of frameshift, its efficiency and other quantities of interest. We also present the stationary phase diagram as a function of the initiation rate and the density ribosomes that the pseudoknot can support. These observations provide mathematically rigorous evidence for the notion that the density of molecular motors is an important control parameter for the elongation rate in the presence of slippery sequences both in transcription of RNA and translation of proteins.
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