Journal
JOURNAL OF POLYMER ENGINEERING
Volume 40, Issue 4, Pages 350-359Publisher
WALTER DE GRUYTER GMBH
DOI: 10.1515/polyeng-2019-0390
Keywords
biocomposites; drug delivery; montmorillonite; polymer blends; specific interactions
Categories
Ask authors/readers for more resources
In this study we report on the preparation and characterization of biocomposites based on a sodium montmorillonite-ibuprofen (Mtlb) hybrid and neat poly(ethylene glycol), neat sodium carboxymethylcellulose or poly(ethylene glycol)-carboxymethylcellulose blend 50/50 biocomposites as drug carriers. Ib, a poorly soluble drug, was first intercalated into sodium Mt and then the resulting hybrid was compounded with the different polymeric matrices. Ib incorporation efficiency in Mt was determined by UV-visible spectroscopy, Fourier transform infrared spectroscopy, X-ray diffraction and thermal analysis. Both X-ray diffraction and differential scanning calorimetric studies revealed that the intercalation of lb between the clay layers induced amorphization of the drug. Differential scanning calorimetry and Fourier transform infrared spectroscopy revealed the development of strong interactions between Ib and the polymer matrix. A study of the release of Ib from the synthesized biocomposites in simulated intestinal fluid (pH 7.4) was investigated. To better understand the release mechanism of drug molecules from the different carriers, several kinetic models have been applied.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available