4.7 Article

Copper-catalyzed oxidative coupling between quinazoline 3-oxides and unactivated aldehydes: an efficient approach to functionalized quinazolines

Journal

CHEMICAL COMMUNICATIONS
Volume 52, Issue 31, Pages 5375-5378

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c6cc00946h

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Funding

  1. National Natural Science Foundation of China [21462023, 21262018]
  2. Natural Science Foundation of Jiangxi Province [20143ACB20007, 20133ACB20008]

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A copper-catalyzed oxidative coupling between quinazoline 3-oxides and unactivated aldehydes was described. The reaction worked well for both aliphatic and aromatic aldehydes and produced not only the direct oxidative coupling ketones but also cyclic hydroxamic esters derived from quinazolines.

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