Journal
CHEMICAL COMMUNICATIONS
Volume 52, Issue 13, Pages 2760-2763Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5cc09092j
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Funding
- Natural Science Foundation of Shandong Province [ZR2014BM004]
- Major Subject of Shandong Province [2015ZDJS04003]
- National Natural Science Foundation of China [91313303]
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A new mitochondria-targeted fluorescent probe HCy-D, constructed by dansyl and hemicyanine fluorophores, for SO2 derivatives (HSO3-/SO32-) was presented. This probe was designed based on a new FRET platform. HCy-D showed a ratiometric, sensitive and rapid response to HSO3-/SO32-. Importantly, HCy-D was successfully used for fluorescence imaging of endogenous bisulfite in HepG2 cells, which may benefit cancer diagnosis by discriminating liver cancer cells from normal liver cells.
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