Journal
CHEMICAL COMMUNICATIONS
Volume 52, Issue 22, Pages 4167-4170Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6cc01238h
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Funding
- Ministry of Science and Technology of ROC [102-2218-E-002-014-MY3, 104-2811-E-002-008, 104-2314-B-195-015]
- Aim for the Top University Plan of the National Taiwan University [104R104005]
- Mackay Memorial Hospital [104-05, 105-04, MMH-CT-10408]
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A label-free and enzyme-free colorimetric sensing platform for the amplified detection of fibronectin was developed based on an ingenious combination of catalytic hairpin assembly and a base stacking hybridization-based gold nanoparticle aggregation strategy. The detection limit of 2.3 pM is at least one order of magnitude lower than that of established fibronectin biosensors.
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