Journal
CHEMICAL COMMUNICATIONS
Volume 52, Issue 99, Pages 14188-14199Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6cc06194j
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Funding
- Natural Science Foundation of China
- Shandong province [21572118, 21372144, JQ201505]
- fundamental research and subject construction funds [2014JC008, 104.205.2.5]
- Zhong-Ying scholar award of Shandong University
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Copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC) is an essential click chemistry'' reaction that is widely used in chemical biology, medicinal chemistry and materials science. The CuAAC reaction of terminal alkynes provides a mild and efficient synthesis of 1,4-disubstituted 1,2,3-triazoles. However, the click reaction of internal alkynes with azides, giving trisubstituted triazoles, is very challenging. This feature article highlights the recent progress addressing this fundamental problem. Particular emphasis is on the current and emerging strategies to introduce functional groups to the C-5 position of triazoles in a regioselective manner.
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