Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 85, Issue 12, Pages 7658-7665Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.9b03470
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Funding
- National Natural Science Foundation of China [21662017, 21961016]
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A three-component cascade reaction of 1,3-enynes, anilines, and Togni-II reagent has been developed to give fully substituted trifluoromethyl pyrroles with high regioselectivity under mild conditions. The transformation proceeds through a Cu(II)/Rh(IID-promoted cascade aza-Michael addition/trifluoromethylation cydization/oxidation reaction, affording trifluoromethyl pyrrole derivatives as primary products.
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