Journal
CHEMICAL COMMUNICATIONS
Volume 52, Issue 6, Pages 1226-1229Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5cc08418k
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Funding
- National Natural Science Foundation of China [21375060, 21135002, 21121091]
- Priority development areas of the National Research Foundation for the Doctoral Program of Higher Education of China [20130091130005]
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A simple and rapid electrochemical sensor is constructed for the detection of telomerase activity based on the electrocatalysis of platinum nanoparticle (Pt NP) encapsulated metal-organic frameworks (MOFs), which are synthesized by one-pot encapsulation of Pt NPs into prototypal MOFs, UiO-66-NH2. Integrating with the efficient electrocatalysis of Pt@MOFs towards NaBH4 oxidation, this biosensor shows the wide dynamic correlation of telomerase activity from 5 x 10(2) to 10(7) HeLa cells mL(-1) and the telomerase activity in a single HeLa cell was calculated to be 2.0 x 10(-11) IU, providing a powerful platform for detecting telomerase activity.
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